Pet Induces IL1, TNFα, MIF and IL1Ra Through the IKKαβ/NFκB Pathway

Pet Induces IL1, TNF , MIF and IL1Ra Through the IKK /NF B Pathway

Plasmid encoded protein (Pet), a product of E. coli, infiltrates leukocyte in experimental models and acts on macrophages as a chemokine. As an immune response orchestrator, macrophages play an important role in inducing proinflammatory cytokines. In this work, we tested whether in macrophages Pet stimulates the expression of IL1, TNF , MIF and the antagonist IL1Ra. We also sought the IKK /NF B...

Reduced IL1Ra/IL1 ratio in UVB-exposed skin of patients with polymorphic light eruption

Iranian crack induces hepatic injury through mitogen-activated protein kinase pathway in the liver of Wistar rat

Objective(s): Iranian crack (IC) is a heroin-based substance manifesting various pathologic side effects. Herein, we aimed to investigate the mechanism of IC-induced liver injuries in Wistar rats. Materials and Methods: Twenty male Wistar rats were randomly divided into two groups: control, and IC (0.9 mg/kg/day/IP, for 30 days). Mitochondrial reactive oxygen species (ROS) production was measur...

ProNGF induces TNFα-dependent death of retinal ganglion cells through a p75 non-cell-autonomous signaling pathway

Department of Pathology and Cell Biology and Groupe de Recherche sur le Système Nerveux Central, Université de Montréal, Montreal, Quebec H3C 3J7, Canada; Centre for Neuronal Survival, Montreal Neurological Institute, Montreal, Quebec H3A 2B4, Canada; Facultés Universitaires Notre-Dame de la Paix School of Medicine, University of Namur, Namur B-5000, Belgium; Centre for Research in Neuroscience...

Neoalbaconol induces cell death through necroptosis by regulating RIPK-dependent autocrine TNFα and ROS production

Necroptosis/regulated necrosis is a caspase-independent, but receptor interacting protein kinase (RIPK)-dependent form of cell death. In previous studies, neoalbaconol (NA), a constituent extracted from Albatrellus confluens, was demonstrated to induce necroptosis in some cancer cell lines. The molecular mechanism of NA-induced necroptosis is described in this research study. We determined that...